Single-molecule technique to explain thermodynamic behavior of complex biomolecular systems


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Most thermodynamic measurements of binding reactions depend on the validity of the regulation of mass motion and the idea of a dilute answer. But, necessary organic methods similar to allosteric ligand-receptor binding, macromolecular crowding, or misfolded molecules might not fulfill these assumptions and should require a specific response mannequin. A brand new article studies that researchers have decided thermodynamic properties in biomolecular complicated methods reminiscent of binding energies, chemical selectivity, and allostery of nucleic acids and peptides in a model-independent method.